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•Introducing•
EL - AGE 
A Comprehensive Measure of Biological Age

As we age, our bodies undergo various biological changes that may not align perfectly with our chronological age—the number of years we've lived. Understanding your biological age can provide valuable insights into your overall health and longevity. To offer a more precise and holistic assessment, we introduce the EL Age (Extended Longevity Age), a harmonized biological age indicator that integrates three key biomarkers of aging: 1. Epigenetic Age (Epigenome Tests), 2. GlycanAge, 3. Telomere Length

Empower Your Aging Journey

Understanding your EL Age is more than just a number—it's a gateway to proactive health management. By knowing where you stand biologically, you can make informed decisions to enhance your well-being, longevity, and quality of life.

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Why EL AGE Matters

  • Holistic Assessment: By integrating multiple biomarkers, EL Age provides a comprehensive picture of your biological aging.

  • Personalized Insights: Understanding your EL Age can help tailor lifestyle choices and interventions to promote healthy aging.

  • Motivation for Healthy Living: Tracking changes in your EL Age over time can motivate you to maintain or adopt health-promoting habits.

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Taking the Next Step

Interested in discovering your EL Age? Here's how you can get started:

  1. Undergo the Tests:

    • Epigenetic Test: Available through specialized labs that analyze DNA methylation patterns.

    • GlycanAge Test: Conducted via a blood test to assess glycan profiles.

    • Telomere Length Measurement: Performed using advanced genomic techniques to determine telomere length in base pairs.

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Understanding the Three Pillars of EL AGE

1. Epigenetic Age (Epigenome Tests)

  • What It Measures: Epigenetic age is determined by analyzing DNA methylation patterns—chemical modifications that regulate gene expression without altering the DNA sequence.

  • Why It's Important: These patterns change predictably as we age and are influenced by environmental factors and lifestyle choices. Epigenetic clocks, like the Horvath clock, provide a highly accurate estimate of biological age.

  • Benefits: Reflects the cumulative effect of various aging processes and can predict age-related diseases and mortality risk.

2. GlycanAge

  • What It Measures: GlycanAge assesses the glycans—complex sugar molecules—attached to immunoglobulin G (IgG) antibodies in your blood.

  • Why It's Important: Glycan patterns change with age and are influenced by inflammation and immune system health.

  • Benefits: Offers insights into immune system aging and chronic inflammation, which are critical factors in overall health and disease development.

3. Telomere Length

  • What It Measures: Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is measured in base pairs (bp).

  • Why It's Important: Short telomeres are associated with cellular aging and increased risk of age-related diseases. Conversely, longer telomeres may indicate a more youthful cellular state.

  • Benefits: Acts as a marker for cellular replicative capacity and biological aging at the cellular level.

Abstract Futuristic Background

The Harmonization Process:

 Calculating Your EL AGE

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To provide a unified and accurate biological age, the EL Age combines these three biomarkers using a weighted model. Here's how it works:

  • Assigning Weights to Each Biomarker

Based on their significance in predicting biological age, each biomarker is assigned a specific weight:

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  • Epigenetic Age Weight (W₁): 0.4 (40%)

  • GlycanAge Weight (W₂): 0.3 (30%)

  • Telomere Length Weight (W₃): 0.3 (30%)

Interpreting Your EL AGE

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  • EL Age vs. Chronological Age: A lower EL Age compared to your chronological age suggests that your biological systems are functioning more youthfully.

  • Negative Telomere-Based Age: This indicates exceptionally long telomeres, above 10,000 bp, reflecting a highly youthful cellular state. They emphasize the positive impact of hyper-long telomeres on biological aging.

References

  • Telomere Biology:

    • Aubert, G., & Lansdorp, P. M. (2008). Telomeres and aging. Physiological Reviews, 88(2), 557-579.

    • Demanelis, K., et al. (2020). Determinants of telomere length across human tissues. Science, 369(6509), eaaz6876.

  • Biological Age Estimation:

    • Belsky, D. W., et al. (2015). Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences, 112(30), E4104-E4110.

    • Mather, K. A., et al. (2011). Is telomere length a biomarker of aging? A review. The Journals of Gerontology Series A, 66(2), 202-213.

  • Hyper-Long Telomeres:

    • Savage, S. A., & Bertuch, A. A. (2010). The genetics and clinical manifestations of telomere biology disorders. Genetics in Medicine, 12(12), 753-764.

  • Epigenetic Aging:

    • Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics, 19(6), 371-384.

    • Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14(10), 3156.

  • GlycanAge:

    • Krištić, J., et al. (2014). Glycans are a novel biomarker of chronological and biological ages. The Journals of Gerontology Series A, 69(7), 779-789.

    • Štambuk, J., et al. (2019). The GlycanAge Test as a New Biomarker of Ageing. Frontiers in Immunology, 10, 2466.

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